Antibody light chain variable domains and their biophysically improved versions for human immunotherapy

We set out to gain deeper insight into the potential of antibody light chain variable domains (V(L)s) as immunotherapeutics. To this end, we generated a naïve human V(L) phage display library and, by using a method previously shown to select for non-aggregating antibody heavy chain variable domains...

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Main Authors: Kim, Dae Young, To, Rebecca, Kandalaft, Hiba, Ding, Wen, van Faassen, Henk, Luo, Yan, Schrag, Joseph D, St-Amant, Nadereh, Hefford, Mary, Hirama, Tomoko, Kelly, John F, MacKenzie, Roger, Tanha, Jamshid
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929445/
https://ncbi.nlm.nih.gov/pubmed/24423624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26844
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