Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human V(H)/V(L) Single-Domain Antibodies from In Vitro Display Libraries

Human autonomous V(H)/V(L) single-domain antibodies (sdAbs) are attractive therapeutic molecules, but often suffer from suboptimal stability, solubility and affinity for cognate antigens. Most commonly, human sdAbs have been isolated from in vitro display libraries constructed via synthetic randomiz...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Henry, Kevin A., Kim, Dae Young, Kandalaft, Hiba, Lowden, Michael J., Yang, Qingling, Schrag, Joseph D., Hussack, Greg, MacKenzie, C. Roger, Tanha, Jamshid
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5763143/
https://ncbi.nlm.nih.gov/pubmed/29375542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01759
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados