Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human V(H)/V(L) Single-Domain Antibodies from In Vitro Display Libraries

Human autonomous V(H)/V(L) single-domain antibodies (sdAbs) are attractive therapeutic molecules, but often suffer from suboptimal stability, solubility and affinity for cognate antigens. Most commonly, human sdAbs have been isolated from in vitro display libraries constructed via synthetic randomiz...

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Vydáno v:Front Immunol
Hlavní autoři: Henry, Kevin A., Kim, Dae Young, Kandalaft, Hiba, Lowden, Michael J., Yang, Qingling, Schrag, Joseph D., Hussack, Greg, MacKenzie, C. Roger, Tanha, Jamshid
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5763143/
https://ncbi.nlm.nih.gov/pubmed/29375542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01759
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