Antibody light chain variable domains and their biophysically improved versions for human immunotherapy

We set out to gain deeper insight into the potential of antibody light chain variable domains (V(L)s) as immunotherapeutics. To this end, we generated a naïve human V(L) phage display library and, by using a method previously shown to select for non-aggregating antibody heavy chain variable domains...

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Detalhes bibliográficos
Main Authors: Kim, Dae Young, To, Rebecca, Kandalaft, Hiba, Ding, Wen, van Faassen, Henk, Luo, Yan, Schrag, Joseph D, St-Amant, Nadereh, Hefford, Mary, Hirama, Tomoko, Kelly, John F, MacKenzie, Roger, Tanha, Jamshid
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929445/
https://ncbi.nlm.nih.gov/pubmed/24423624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26844
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