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Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells
Methotrexate and [(3)H]methotrexate were conjugated through a carbodiimide-catalyzed reaction to a 70,000 molecular weight poly(L-lysine) in molar ratios of approximately 13 to 1. The cellular uptake of labeled conjugate was far in excess of the uptake of free drug in cells that were either proficie...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1978
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392889/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/279001/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.8.3867 |
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