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Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter

Pgp is functional on the plasma membrane and lysosomal membrane. Lysosomal-Pgp can pump substrates into the organelle, thereby trapping certain chemotherapeutics (e.g. doxorubicin; DOX). This mechanism serves as a “safe house” to protect cells against cytotoxic drugs. Interestingly, in contrast to D...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Seebacher, Nicole A., Lane, Darius J. R., Jansson, Patric J., Richardson, Des R.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759162/
https://ncbi.nlm.nih.gov/pubmed/26601947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.682450
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