Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)

Multidrug resistance (MDR) is a major obstacle in cancer treatment. More than half of human cancers express multidrug-resistant P-glycoprotein (Pgp), which correlates with a poor prognosis. Intriguingly, through an unknown mechanism, some drugs have greater activity in drug-resistant tumor cells tha...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jansson, Patric J., Yamagishi, Tetsuo, Arvind, Akanksha, Seebacher, Nicole, Gutierrez, Elaine, Stacy, Alexandra, Maleki, Sanaz, Sharp, Danae, Sahni, Sumit, Richardson, Des R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392262/
https://ncbi.nlm.nih.gov/pubmed/25720491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.631283
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