The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms

BACKGROUND: Neuroblastoma is a relatively common and highly belligerent childhood tumor with poor prognosis by current therapeutic approaches. A novel anti-cancer agent of the di-2-pyridylketone thiosemicarbazone series, namely di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), demonstrat...

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Detalles Bibliográficos
Publicado en:J Hematol Oncol
Main Authors: Guo, Zhu-Ling, Richardson, Des R., Kalinowski, Danuta S., Kovacevic, Zaklina, Tan-Un, Kian Cheng, Chan, Godfrey Chi-Fung
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039880/
https://ncbi.nlm.nih.gov/pubmed/27678372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0330-x
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