Iron Chelators of the Di-2-pyridylketone Thiosemicarbazone and 2-Benzoylpyridine Thiosemicarbazone Series Inhibit HIV-1 Transcription: Identification of Novel Cellular Targets—Iron, Cyclin-Dependent Kinase (CDK) 2, and CDK9

HIV-1 transcription is activated by HIV-1 Tat protein, which recruits cyclin-dependent kinase 9 (CDK9)/cyclin T1 and other host transcriptional coactivators to the HIV-1 promoter. Tat itself is phosphorylated by CDK2, and inhibition of CDK2 by small interfering RNA, the iron chelator 2-hydroxy-1-nap...

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Main Authors: Debebe, Zufan, Ammosova, Tatyana, Breuer, Denitra, Lovejoy, David B., Kalinowski, Danuta S., Karla, Pradeep K., Kumar, Krishna, Jerebtsova, Marina, Ray, Patricio, Kashanchi, Fatah, Gordeuk, Victor R., Richardson, Des R., Nekhai, Sergei
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014282/
https://ncbi.nlm.nih.gov/pubmed/20956357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.069062
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