Development of a Sensitive HPLC Method to Measure In-Vitro Permeability of E- and Z-Isomeric Forms of Thiosemicarbazones in Caco-2 Monolayers

In the current study, we developed a HPLC method to quantitatively measure the permeability of the BpT-based chelators, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone (Bp4eT) and 2-benzoylpyridine 4-allyl-3-thiosemicarbazone (Bp4aT), across human colorectal adenocarcinoma (Caco-2) monolayers as a mod...

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Detalhes bibliográficos
Main Authors: Debebe, Zufan, Nekhai, Sergei, Ashenafi, Meseret, Lovejoy, David B., Kalinowski, Danuta S., Gordeuk, Victor R., Byrnes, W. Malcolm, Richardson, Des R., Karla, Pradeep K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457786/
https://ncbi.nlm.nih.gov/pubmed/22954966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2012.08.011
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