CDK2 Regulates HIV-1 Transcription by Phosphorylation of CDK9 on Serine 90

BACKGROUND: HIV-1 transcription is activated by the viral Tat protein that recruits host positive transcription elongation factor-b (P-TEFb) containing CDK9/cyclin T1 to the HIV-1 promoter. P-TEFb in the cells exists as a lower molecular weight CDK9/cyclin T1 dimer and a high molecular weight comple...

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Hauptverfasser: Breuer, Denitra, Kotelkin, Alexander, Ammosova, Tatiana, Kumari, Namita, Ivanov, Andrey, Ilatovskiy, Andrey V, Beullens, Monique, Roane, Philip R, Bollen, Mathieu, Petukhov, Michael G, Kashanchi, Fatah, Nekhai, Sergei
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3515335/
https://ncbi.nlm.nih.gov/pubmed/23140174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-94
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