Iron depletion by iron chelators or ferroportin inhibits HIV-1 through the induction of HIF1α, p21 and IKBα and the inhibition of CDK9 and CDK2

Eitemau Tebyg

• Phenyl-1-Pyridin-2yl-Ethanone-Based Iron Chelators Increase IκB-α Expression, Modulate CDK2 and CDK9 Activities, and Inhibit HIV-1 Transcription
  gan: Kumari, Namita, et al.
  Cyhoeddwyd: (2014)
• Regulation of CDK9 Activity by Phosphorylation and Dephosphorylation
  gan: Nekhai, Sergei, et al.
  Cyhoeddwyd: (2014)
• Iron Chelators of the Di-2-pyridylketone Thiosemicarbazone and 2-Benzoylpyridine Thiosemicarbazone Series Inhibit HIV-1 Transcription: Identification of Novel Cellular Targets—Iron, Cyclin-Dependent Kinase (CDK) 2, and CDK9
  gan: Debebe, Zufan, et al.
  Cyhoeddwyd: (2011)
• Protein Phosphatase-1 –targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals
  gan: Lin, Xionghao, et al.
  Cyhoeddwyd: (2017)
• Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease
  gan: Kumari, Namita, et al.
  Cyhoeddwyd: (2016)