Poly(amidoamine) Dendrimer–Methotrexate Conjugates: The Mechanism of Interaction with Folate Binding Protein

[Image: see text] Generation 5 poly(amidoamine) (G5 PAMAM) methotrexate (MTX) conjugates employing two small molecular linkers, G5-(COG-MTX)(n), G5-(MFCO-MTX)(n) were prepared along with the conjugates of the G5-G5 (D) dimer, D-(COG-MTX)(n), D-(MFCO-MTX)(n). The monomer G5-(COG-MTX)(n) conjugates ex...

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Pubblicato in:Mol Pharm
Autori principali: van Dongen, Mallory A., Rattan, Rahul, Silpe, Justin, Dougherty, Casey, Michmerhuizen, Nicole L., Van Winkle, Margaret, Huang, Baohua, Choi, Seok Ki, Sinniah, Kumar, Orr, Bradford G., Banaszak Holl, Mark M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224518/
https://ncbi.nlm.nih.gov/pubmed/25222480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500608s
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