Poly(amidoamine) Dendrimer–Methotrexate Conjugates: The Mechanism of Interaction with Folate Binding Protein

[Image: see text] Generation 5 poly(amidoamine) (G5 PAMAM) methotrexate (MTX) conjugates employing two small molecular linkers, G5-(COG-MTX)(n), G5-(MFCO-MTX)(n) were prepared along with the conjugates of the G5-G5 (D) dimer, D-(COG-MTX)(n), D-(MFCO-MTX)(n). The monomer G5-(COG-MTX)(n) conjugates ex...

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Publicado en:Mol Pharm
Main Authors: van Dongen, Mallory A., Rattan, Rahul, Silpe, Justin, Dougherty, Casey, Michmerhuizen, Nicole L., Van Winkle, Margaret, Huang, Baohua, Choi, Seok Ki, Sinniah, Kumar, Orr, Bradford G., Banaszak Holl, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224518/
https://ncbi.nlm.nih.gov/pubmed/25222480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500608s
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