Avidity Modulation of Folate-Targeted Multivalent Dendrimers for Evaluating Biophysical Models of Cancer Targeting Nanoparticles

We investigated two types of generation 5 polyamidoamine (PAMAM) dendrimers, each conjugated stochastically with a mean number of five or ten methotrexate (MTX) ligands per dendrimer (G5-MTX(5), G5-MTX(10)), for their binding to surface-immobilized folate binding protein (FBP) as a function of recep...

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Detalhes bibliográficos
Main Authors: Silpe, Justin E., Sumit, Madhuresh, Thomas, Thommey P., Huang, Baohua, Kotlyar, Alina, van Dongen, Mallory A., Banaszak Holl, Mark M., Orr, Bradford G., Choi, Seok Ki
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783574/
https://ncbi.nlm.nih.gov/pubmed/23855478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400258d
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