Polyvalent Dendrimer-Methotrexate as a Folate Receptor-Targeted Cancer Therapeutic

Our previous studies have demonstrated that a generation 5 dendrimer (G5) conjugated with both folic acid (FA) and methotrexate (MTX) has a higher chemotherapeutic index than MTX alone. Despite this, batch-to-batch inconsistencies in the number of FA and MTX molecules linked to each dendrimer led to...

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Bibliografiske detaljer
Udgivet i:Mol Pharm
Main Authors: Thomas, Thommey P., Huang, Baohua, Choi, Seok Ki, Silpe, Justin E., Kotlyar, Alina, Desai, Ankur M., Zong, Hong, Gam, Jeremy, Joice, Melvin, Baker, James R.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457335/
https://ncbi.nlm.nih.gov/pubmed/22827500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp3002232
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