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Design and In vitro Validation of Multivalent Dendrimer Methotrexates as a Folate-targeting Anticancer Therapeutic

Design of cancer-targeting nanotherapeutics relies on a pair of two functionally orthogonal molecules, one serving as a cancer cell-specific targeting ligand, and the other as a therapeutic cytotoxic agent. The present study investigates the validity of an alternative simplified strategy where a dua...

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Autores principales: Thomas, Thommey P., Joice, Melvin, Sumit, Madhuresh, Silpe, Justin E., Kotlyar, Alina, Bharathi, Sophia, Kukowska-Latallo, Jolanta, Baker, James R., Choi, Seok Ki
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859140/
https://ncbi.nlm.nih.gov/pubmed/23621534
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