Polyvalent Saccharide-Functionalized Generation 3 Poly (amidoamine) Dendrimer-Methotrexate Conjugate as a Potential Anticancer Agent

A saccharide-terminated Generation 3 (G3) polyamidoamine (PAMAM) dendrimer was synthesized as a drug carrier. Utilizing this dendritic platform, we have successfully synthesized polyvalent conjugates (G3-MTX) containing the drug methotrexate (MTX). Surface plasmon resonance (SPR) results showed that...

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Autors principals: Zhang, Yuehua, Thomas, Thommey P., Lee, Kyung-Hoon, Li, Minghsin, Zong, Hong, Desai, Ankur M., Kotlyar, Alina, Huang, Baohua, Banaszak Holl, Mark M., Baker, James R.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130541/
https://ncbi.nlm.nih.gov/pubmed/21459000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.03.019
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