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HER2 specific Delivery of Methotrexate by Dendrimer Conjugated anti-HER2 mAb
Herceptin a humanized monoclonal antibody that binds to human growth factor receptor-2 (HER2) was covalently attached to a fifth-generation (G5) polyamidoamine dendrimer containing the cytotoxic drug methotrexate. The specific binding and internalization of this conjugate labeled with FITC was clear...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913620/ https://ncbi.nlm.nih.gov/pubmed/20686639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1088/0957-4484/19/29/295102 |
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