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A Statistical Framework to Guide Sequencing Choices in Pedigrees

The use of large pedigrees is an effective design for identifying rare functional variants affecting heritable traits. Cost-effective studies using sequence data can be achieved via pedigree-based genotype imputation in which some subjects are sequenced and missing genotypes are inferred on the rema...

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Bibliografske podrobnosti
Main Authors: Cheung, Charles Y.K., Marchani Blue, Elizabeth, Wijsman, Ellen M.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928665/
https://ncbi.nlm.nih.gov/pubmed/24507777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2014.01.005
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