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The role of large pedigrees in an era of high-throughput sequencing

Rare variation is the current frontier in human genetics. The large pedigree design is practical, efficient, and well-suited for investigating rare variation. In large pedigrees, specific rare variants that co-segregate with a trait will occur in sufficient numbers so that effects can be measured, a...

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Detalhes bibliográficos
Autor principal: Wijsman, Ellen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638020/
https://ncbi.nlm.nih.gov/pubmed/22714655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-012-1190-2
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