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A Statistical Framework to Guide Sequencing Choices in Pedigrees
The use of large pedigrees is an effective design for identifying rare functional variants affecting heritable traits. Cost-effective studies using sequence data can be achieved via pedigree-based genotype imputation in which some subjects are sequenced and missing genotypes are inferred on the rema...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3928665/ https://ncbi.nlm.nih.gov/pubmed/24507777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2014.01.005 |
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