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Molecular Mechanisms of Influenza Inhibition by Surfactant Protein D Revealed by Large-scale Molecular Dynamics Simulation
Surfactant protein D (SP-D), a mammalian C-type lectin, is the primary innate inhibitor of influenza A virus (IAV) in the lung. SP-D interactions with highly branched viral N-linked glycans on hemagglutinin (HA), an abundant IAV envelope protein and critical virulence factor, promote viral aggregati...
में बचाया:
मुख्य लेखकों: | , , , , , , , , , , |
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स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
2013
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विषय: | |
ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3927399/ https://ncbi.nlm.nih.gov/pubmed/24224757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4010683 |
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