Molecular Mechanisms of Influenza Inhibition by Surfactant Protein D Revealed by Large-scale Molecular Dynamics Simulation

Surfactant protein D (SP-D), a mammalian C-type lectin, is the primary innate inhibitor of influenza A virus (IAV) in the lung. SP-D interactions with highly branched viral N-linked glycans on hemagglutinin (HA), an abundant IAV envelope protein and critical virulence factor, promote viral aggregati...

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Main Authors: Goh, Boon Chong, Rynkiewicz, Michael J., Cafarella, Tanya R., White, Mitchell R., Hartshorn, Kevan L., Allen, Kimberly, Crouch, Erika C., Calin, Oliviana, Seeberger, Peter H., Schulten, Klaus, Seaton, Barbara A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927399/
https://ncbi.nlm.nih.gov/pubmed/24224757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4010683
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