Mutagenesis of Surfactant Protein D Informed by Evolution and X-ray Crystallography Enhances Defenses against Influenza A Virus in Vivo

The recognition of influenza A virus (IAV) by surfactant protein D (SP-D) is mediated by interactions between the SP-D carbohydrate recognition domains (CRD) and glycans displayed on envelope glycoproteins. Although native human SP-D shows potent antiviral and aggregating activity, trimeric recombin...

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Hauptverfasser: Crouch, Erika, Nikolaidis, Nikolaos, McCormack, Francis X., McDonald, Barbara, Allen, Kimberly, Rynkiewicz, Michael J., Cafarella, Tanya M., White, Mitchell, Lewnard, Kara, Leymarie, Nancy, Zaia, Joseph, Seaton, Barbara A., Hartshorn, Kevan L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220461/
https://ncbi.nlm.nih.gov/pubmed/21965658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.300673
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