Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses

We recently reported that a trimeric neck and carbohydrate recognition domain (NCRD) fragment of human surfactant protein D (SP-D), a host defense lectin, with combinatorial substitutions at the 325 and 343 positions (D325A+R343V) exhibits markedly increased antiviral activity for seasonal strains o...

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Detalhes bibliográficos
Main Authors: Nikolaidis, Nikolaos M., White, Mitchell R., Allen, Kimberly, Tripathi, Shweta, Qi, Li, McDonald, Barbara, Taubenberger, Jeffery, Seaton, Barbara A., McCormack, Francis X., Crouch, Erika C., Hartshorn, Kevan L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042192/
https://ncbi.nlm.nih.gov/pubmed/24705721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00035.2014
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