Enhancement of Antiviral Activity of Collectin Trimers through Cross-Linking and Mutagenesis of the Carbohydrate Recognition Domain

Surfactant protein D (SP-D) plays important roles in innate defense against respiratory viruses [including influenza A viruses (IAVs)]. Truncated trimers composed of its neck and carbohydrate recognition domains (NCRDs) bind various ligands; however, they have minimal inhibitory activity for IAV. We...

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Detalhes bibliográficos
Main Authors: White, Mitchell R., Boland, Patrick, Tecle, Tesfaldet, Gantz, Donald, Sorenson, Grith, Tornoe, Ida, Holmskov, Uffe, McDonald, Barbara, Crouch, Erika C., Hartshorn, Kevan L.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956016/
https://ncbi.nlm.nih.gov/pubmed/20375547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000272313
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