Increasing Antiviral Activity of Surfactant Protein D Trimers By Introducing Residues From Bovine Serum Collectins: Dissociation of mannan-binding and antiviral activity

Collectins contribute to host defense through interactions with glycoconjugates on pathogen surfaces. We have prepared recombinant trimeric neck and carbohydrate recognition domains (NCRDs) of collectins and we now show that the NCRDs of bovine conglutinin and CL-46 (like that of CL-43) have greater...

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Detalhes bibliográficos
Main Authors: Hartshorn, Kevan L., White, Mitchell R., Smith, Kelly, Sorensen, Grith, Kuroki, Yoshio, Holmskov, Uffe, Head, James, Crouch, Erika C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263973/
https://ncbi.nlm.nih.gov/pubmed/20591072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-3083.2010.02409.x
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