Increasing Antiviral Activity of Surfactant Protein D Trimers By Introducing Residues From Bovine Serum Collectins: Dissociation of mannan-binding and antiviral activity

Collectins contribute to host defense through interactions with glycoconjugates on pathogen surfaces. We have prepared recombinant trimeric neck and carbohydrate recognition domains (NCRDs) of collectins and we now show that the NCRDs of bovine conglutinin and CL-46 (like that of CL-43) have greater...

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Main Authors: Hartshorn, Kevan L., White, Mitchell R., Smith, Kelly, Sorensen, Grith, Kuroki, Yoshio, Holmskov, Uffe, Head, James, Crouch, Erika C.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263973/
https://ncbi.nlm.nih.gov/pubmed/20591072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-3083.2010.02409.x
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