Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells

Hyperactivation of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase is prevalent in human lung cancer and its inhibition by the tyrosine kinase inhibitors (TKIs), including gefitinib and erlotinib, initially controls tumor growth. However, most patients ultimately relapse due to the developme...

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Detaylı Bibliyografya
Asıl Yazarlar: Wu, Kai, Chang, Qingshan, Lu, Yongju, Qiu, Ping, Chen, Bailing, Thakur, Chitra, Sun, Jiaying, Li, Lingzhi, Kowluru, Anjaneyulu, Chen, Fei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2013
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926838/
https://ncbi.nlm.nih.gov/pubmed/24280348
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