Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells

Hyperactivation of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase is prevalent in human lung cancer and its inhibition by the tyrosine kinase inhibitors (TKIs), including gefitinib and erlotinib, initially controls tumor growth. However, most patients ultimately relapse due to the developme...

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Detalhes bibliográficos
Main Authors: Wu, Kai, Chang, Qingshan, Lu, Yongju, Qiu, Ping, Chen, Bailing, Thakur, Chitra, Sun, Jiaying, Li, Lingzhi, Kowluru, Anjaneyulu, Chen, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926838/
https://ncbi.nlm.nih.gov/pubmed/24280348
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