Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence

Clostridium difficile causes antibiotic-associated diarrhea and pseudomembranous colitis by the actions of Rho-glucosylating toxins A and B. Recently identified hypervirulent strains, which are associated with increased morbidity and mortality, additionally produce the actin-ADP–ribosylating toxin C...

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Hlavní autoři: Schwan, Carsten, Kruppke, Anna S., Nölke, Thilo, Schumacher, Lucas, Koch-Nolte, Friedrich, Kudryashev, Mikhail, Stahlberg, Henning, Aktories, Klaus
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926047/
https://ncbi.nlm.nih.gov/pubmed/24469807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311589111
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