Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT)

Hypervirulent Clostridium difficile strains, which are associated with increased morbidity and mortality, produce the actin-ADP ribosylating toxin Clostridium difficile transferase (CDT). CDT depolymerizes actin, causes formation of microtubule-based protrusions, and increases pathogen adherence. He...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Nölke, Thilo, Schwan, Carsten, Lehmann, Friederike, Østevold, Kristine, Pertz, Olivier, Aktories, Klaus
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948358/
https://ncbi.nlm.nih.gov/pubmed/27339141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522717113
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