Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT

The spore-forming gut bacterium Clostridium difficile is the leading cause of antibiotic-associated diarrhea in hospitalized patients. The major virulence factors are two large glucosylating cytotoxins. Hypervirulent strains (e.g. ribotype 027) with higher morbidity and mortality additionally produc...

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Pubblicato in:Sci Rep
Autori principali: Unger, Mandy, Eichhoff, Anna Marei, Schumacher, Lucas, Strysio, Moritz, Menzel, Stephan, Schwan, Carsten, Alzogaray, Vanina, Zylberman, Vanesa, Seman, Michel, Brandner, Johanna, Rohde, Holger, Zhu, Kai, Haag, Friedrich, Mittrücker, Hans-Willi, Goldbaum, Fernando, Aktories, Klaus, Koch-Nolte, Friedrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297958/
https://ncbi.nlm.nih.gov/pubmed/25597743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07850
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