Small Molecule Inhibitors of Anthrax Lethal Factor Toxin

This manuscript describes the preparation of new small molecule inhibitors of Bacillus anthracis lethal factor. Our starting point was the symmetrical, bis-quinolinyl compound 1 (NSC 12155). Optimization of one half of this molecule led to new LF inhibitors that were desymmetrized to afford more dru...

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Bibliographic Details
Main Authors: Williams, John D., Khan, Atiyya R., Cardinale, Steven C., Butler, Michelle M., Bowlin, Terry L., Peet, Norton P.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925373/
https://ncbi.nlm.nih.gov/pubmed/24290062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.11.009
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