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Promoter Hypermethylation of KLF4 Inactivates Its Tumor Suppressor Function in Cervical Carcinogenesis
OBJECTIVE: The KLF4 gene has been shown to be inactivated in cervical carcinogenesis as a tumor suppressor. However, the mechanism of KLF4 silencing in cervical carcinomas has not yet been identified. DNA methylation plays a key role in stable suppression of gene expression. METHODS: The methylation...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3925171/ https://ncbi.nlm.nih.gov/pubmed/24551169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088827 |
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