Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow

How stem cells interact with the microenvironment to regulate their cell fates and metabolism is largely unknown. Here we demonstrated that the deletion of the cytoskeleton-modulating protein profilin 1 (pfn1) in hematopoietic stem cell (HSCs) led to bone marrow failure, loss of quiescence, and mobi...

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Hlavní autoři: Zheng, Junke, Lu, Zhigang, Kocabas, Fatih, Böttcher, Ralph T., Costell, Mercedes, Kang, Xunlei, Liu, Xiaoye, DeBerardinis, Ralph J., Wang, Qianming, Chen, Guo-Qiang, Sadek, Hesham, Zhang, Cheng Cheng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924932/
https://ncbi.nlm.nih.gov/pubmed/24385538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-498469
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