Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow

How stem cells interact with the microenvironment to regulate their cell fates and metabolism is largely unknown. Here we demonstrated that the deletion of the cytoskeleton-modulating protein profilin 1 (pfn1) in hematopoietic stem cell (HSCs) led to bone marrow failure, loss of quiescence, and mobi...

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Detalhes bibliográficos
Main Authors: Zheng, Junke, Lu, Zhigang, Kocabas, Fatih, Böttcher, Ralph T., Costell, Mercedes, Kang, Xunlei, Liu, Xiaoye, DeBerardinis, Ralph J., Wang, Qianming, Chen, Guo-Qiang, Sadek, Hesham, Zhang, Cheng Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924932/
https://ncbi.nlm.nih.gov/pubmed/24385538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-498469
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