Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow

How stem cells interact with the microenvironment to regulate their cell fates and metabolism is largely unknown. Here we demonstrated that the deletion of the cytoskeleton-modulating protein profilin 1 (pfn1) in hematopoietic stem cell (HSCs) led to bone marrow failure, loss of quiescence, and mobi...

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Autors principals: Zheng, Junke, Lu, Zhigang, Kocabas, Fatih, Böttcher, Ralph T., Costell, Mercedes, Kang, Xunlei, Liu, Xiaoye, DeBerardinis, Ralph J., Wang, Qianming, Chen, Guo-Qiang, Sadek, Hesham, Zhang, Cheng Cheng
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2014
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924932/
https://ncbi.nlm.nih.gov/pubmed/24385538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-498469
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