Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor regulating C. elegans development and lifespan

Small-molecule ligands of nuclear hormone receptors (NHRs) govern the transcriptional regulation of metazoan development, cell differentiation, and metabolism. However, the physiological ligands of many NHRs remain poorly characterized primarily due to lack of robust analytical techniques. Using com...

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Main Authors: Mahanti, Parag, Bose, Neelanjan, Bethke, Axel, Judkins, Joshua C., Wollam, Joshua, Dumas, Kathleen J., Zimmerman, Anna M., Campbell, Sydney L., Hu, Patrick J., Antebi, Adam, Schroeder, Frank C.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924769/
https://ncbi.nlm.nih.gov/pubmed/24411940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.11.024
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