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A Nuclear Receptor Ligand-based Probe Enables Temporal Control of C. elegans Development
C. elegans development and lifespan are controlled by the nuclear hormone receptor DAF-12, an important model for vertebrate vitamin D and liver-X receptors. Similar to its mammalian homologs, DAF-12 function is regulated by bile acid-like steroidal ligands, the dafachronic acids; however, tools for...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4016105/ https://ncbi.nlm.nih.gov/pubmed/24453122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201307465 |
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