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Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor regulating C. elegans development and lifespan

Small-molecule ligands of nuclear hormone receptors (NHRs) govern the transcriptional regulation of metazoan development, cell differentiation, and metabolism. However, the physiological ligands of many NHRs remain poorly characterized primarily due to lack of robust analytical techniques. Using com...

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書誌詳細
主要な著者: Mahanti, Parag, Bose, Neelanjan, Bethke, Axel, Judkins, Joshua C., Wollam, Joshua, Dumas, Kathleen J., Zimmerman, Anna M., Campbell, Sydney L., Hu, Patrick J., Antebi, Adam, Schroeder, Frank C.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924769/
https://ncbi.nlm.nih.gov/pubmed/24411940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.11.024
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