Knockdown of Both Mitochondrial Isocitrate Dehydrogenase Enzymes In Pancreatic Beta Cells Inhibits Insulin Secretion

BACKGROUND: There are three isocitrate dehydrogenases (IDHs) in the pancreatic insulin cell; IDH1 (cytosolic) and IDH2 (mitochondrial) use NADP(H). IDH3 is mitochondrial, uses NAD(H) and was believed to be the IDH that supports the citric acid cycle. METHODS: With shRNAs targeting mRNAs for these en...

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Bibliographic Details
Main Authors: MacDonald, Michael J., Brown, Laura J., Longacre, Melissa J., Stoker, Scott W., Kendrick, Mindy A., Hasan, Noaman M.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923500/
https://ncbi.nlm.nih.gov/pubmed/23876293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2013.07.013
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