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The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome
After undergoing massive RNA and protein rearrangements during assembly, the spliceosome undergoes a final, more subtle, ATP-dependent rearrangement that is essential for catalysis. This rearrangement requires the DEAH-box protein Prp2p, an RNA-dependent ATPase. Prp2p has been implicated in destabil...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3923124/ https://ncbi.nlm.nih.gov/pubmed/24442613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.042598.113 |
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