Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL

Hypoxia and doxorubicin can cause cardiotoxicity and loss of myocardial function. These effects are due, in part, to an induction of apoptosis. Herein we identify the apoptotic pathways activated in H9c2 cells in response to hypoxia (O(2)/N(2)/CO(2), 0.5:94.5:5) and doxorubicin (0.5 μM). Although th...

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Autori principali: Reeve, Janice LV, Szegezdi, Eva, Logue, Susan E, Chonghaile, Tríona Ní, O’Brien, Timothy, Ritter, Thomas, Samali, Afshin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2007
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922357/
https://ncbi.nlm.nih.gov/pubmed/17635642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2007.00042.x
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