Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL

Hypoxia and doxorubicin can cause cardiotoxicity and loss of myocardial function. These effects are due, in part, to an induction of apoptosis. Herein we identify the apoptotic pathways activated in H9c2 cells in response to hypoxia (O(2)/N(2)/CO(2), 0.5:94.5:5) and doxorubicin (0.5 μM). Although th...

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Detaylı Bibliyografya
Asıl Yazarlar: Reeve, Janice LV, Szegezdi, Eva, Logue, Susan E, Chonghaile, Tríona Ní, O’Brien, Timothy, Ritter, Thomas, Samali, Afshin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Publishing Ltd 2007
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922357/
https://ncbi.nlm.nih.gov/pubmed/17635642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2007.00042.x
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