Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin

High-grade conventional osteosarcoma is the most common primary bone tumor. Prognosis for osteosarcoma patients is poor and resistance to chemotherapy is common. We performed an siRNA screen targeting members of the Bcl-2 family in human osteosarcoma cell lines to identify critical regulators of ost...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Baranski, Zuzanna, de Jong, Yvonne, Ilkova, Trayana, Peterse, Elisabeth F.P., Cleton-Jansen, Anne-Marie, van de Water, Bob, Hogendoorn, Pancras C.W., Bovée, Judith V.M.G., Danen, Erik H.J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742165/
https://ncbi.nlm.nih.gov/pubmed/26416351
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