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Cytokine-induced β-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-X(L)
Pro-inflammatory cytokines are implicated as the main mediators of β-cell death during type 1 diabetes but the exact mechanisms remain unknown. This study examined the effects of interleukin-1β (IL-1β), interferon-γ (IFNγ) and tumour necrosis factor α (TNFα) on a rat insulinoma cell line (RIN-r) in...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Blackwell Publishing Ltd
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3822546/ https://ncbi.nlm.nih.gov/pubmed/18081694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2007.00191.x |
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