Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms.

A hydrophobic cleft formed by the BH1, BH2 and BH3 domains of Bcl-xL is responsible for interactions between Bcl-xL and BH3-containing death agonists. Mutants were constructed which did not bind to Bax but retained anti-apoptotic activity. Since Bcl-xL can form an ion channel in synthetic lipid memb...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Minn, A J, Kettlun, C S, Liang, H, Kelekar, A, Vander Heiden, M G, Chang, B S, Fesik, S W, Fill, M, Thompson, C B
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1999
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171156/
https://ncbi.nlm.nih.gov/pubmed/9927423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.3.632
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