Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells

Valency requirements for B cell activation upon antigen encounter are poorly understood. OB1 transnuclear B cells express an IgG1 B cell receptor (BCR) specific for ovalbumin (OVA), the epitope of which can be mimicked using short synthetic peptides to allow antigen-specific engagement of the BCR. B...

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Bibliographic Details
Main Authors: Avalos, Ana M., Bilate, Angelina M., Witte, Martin D., Tai, Albert K., He, Jiang, Frushicheva, Maria P., Thill, Peter D., Meyer-Wentrup, Friederike, Theile, Christopher S., Chakraborty, Arup K., Zhuang, Xiaowei, Ploegh, Hidde L.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920557/
https://ncbi.nlm.nih.gov/pubmed/24493799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131603
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