Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT

Lymphocytes, such as T cells, undergo genetic V(D)J recombination, to generate a receptor with a certain specificity(1). Mice transgenic for a rearranged antigen-specific T cell receptor (TCR) have been an indispensable tool to study T cell development and function. However, such TCRs are usually is...

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Bibliographische Detailangaben
Hauptverfasser: Kirak, Oktay, Frickel, Eva-Maria, Grotenbreg, Gijsbert M., Suh, Heikyung, Jaenisch, Rudolf, Ploegh, Hidde L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MyJove Corporation 2010
Schlagworte:
Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157875/
https://ncbi.nlm.nih.gov/pubmed/20972401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/2168
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