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A cyclobutane thymine–N(4)-methylcytosine dimer is resistant to hydrolysis but strongly blocks DNA synthesis
Exposure of DNA to ultraviolet light produces harmful crosslinks between adjacent pyrimidine bases, to form cyclobutane pyrimidine dimers (CPDs) and pyrimidine(6–4)pyrimidone photoproducts. The CPD is frequently formed, and its repair mechanisms have been exclusively studied by using a CPD formed at...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3919605/ https://ncbi.nlm.nih.gov/pubmed/24185703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1039 |
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